In Biologic-Naïve patients, JYSELECA demonstrated histologic remission in a significantly greater proportion of patients vs. placebo at Week 101
**** P < 0.0001 JYSELECA vs placebo.
Histologic remission was defined as no or mild increase in chronic inflammatory infiltrate in the lamina propria, no neutrophils in the lamina propria or epithelium, and no erosion, ulceration, or granulation tissue using Geboes Index: Grade 0 of ≤0.3, Grade 1 of ≤1.1, Grade 2a of ≤2A.3, Grade 2b of 2B.0, Grade 3 of 3.0, Grade 4 of 4.0, and Grade 5 of 5.0 (centrally read).1
Reference: 1. Feagan BG, Danese S, Loftus EV Jr, et al. Lancet 2021;397:2372–2384