Rheumatoid Arthritis

About JAK-STAT

Introduction


Find out more about the unique role of JAKs in cytokine signalling, with detailed content and teaching materials on RA pathogenesis.

Pathogenesis of inflammatory diseases

The JAK-STAT pathway plays a central role in chronic inflammatory diseases, such as rheumatoid arthritis (RA).1,2

In RA, inflammation is the major contributor to disability in early disease; radiographic progression dominates disability later in the disease process.3

Disease progression in RA4

Dysregulation of immune response ignites the uncontrolled inflammation of RA, which is fuelled by excessive signalling via the JAK-STAT pathway.1,5

Pathogenesis

Excessive signalling via the JAK-STAT pathway fuels inflammation.6
The pathogenesis of inflammatory diseases

Summary

JAK-STAT Pathway

Find out more about the JAK-STAT pathway.

Related

Unmet Needs

Take a closer look at the unmet needs of patients with RA

JAK-STAT Pathway

Learn more about the JAK-STAT pathway

Discover our product information for rheumatoid arthritis

HCP, healthcare provider; JAK, Janus kinase; RA, rheumatoid arthritis; STAT, signal transducer and activator of transcription.


REFERENCES

1. Malemud CJ. Integr J Mol Med. 2017;18(3). Pii:E484. 2. Banerjee S, Biehl A, Gadina M, Hasni S, Schwartz DM. Drugs. 2017;77(5):521-546. 3. Emery P, McInnes IB, van Vollenhoven R, Kraan MC. Rheumatology (Oxford). 2008;47(4):392-398. 4. Kirwan JR. J Rheumatol. 1999;26(3):720-725. 5. Hodge JA, et al. Clin Exp Rheumatol. 2016;34(2):318-328. 6. McInnes IB, Liew FY. Nat Clin Pract Rheumatol. 2005;1(1):31-39.