Introducing the JAK-STAT pathway
Discusses the immune system as a complex network that relies on cytokines to respond to pathogens. Highlights the role of key JAK-dependent cytokines in various processes associated with RA pathogenesis.
Cytokines and JAK family proteins
Introduces the unique cytokine profiles of the JAK proteins. Discusses the selective association of certain JAK pairs with cytokine receptors and explains their distinct roles in RA pathogenesis.
Regulation of the immune response by the JAK family proteins
Introduces and details the structural similarities between the JAK family of proteins (JAK1, JAK2, JAK3, and TYK2). Discusses differences in immunological function between JAK family proteins.
The role of cytokines in the JAK-STAT pathway
Details JAK-mediated cytokine signalling and highlights key cytokines associated with RA (IL-6, IL-21, GM-CSF) and their role in disease pathogenesis.
GM-CSF, Granulocyte-macrophage colony-stimulating factor; IL, interleukin; JAK, Janus kinase; RA, rheumatoid arthritis; STAT, signal transducer and activator of transcription; TYK, tyrosine kinase.