Rheumatoid Arthritis

JAK-STAT Expert Videos

Introduction

Experts discuss RA pathogenesis

Videos

JAK-STAT Expert—DR. WINTHROP

Introducing the JAK-STAT pathway

Discusses the immune system as a complex network that relies on cytokines to respond to pathogens. Highlights the role of key JAK-dependent cytokines in various processes associated with RA pathogenesis.

JAK-STAT Expert—DR. TAYLOR

Cytokines and JAK family proteins

Introduces the unique cytokine profiles of the JAK proteins. Discusses the selective association of certain JAK pairs with cytokine receptors and explains their distinct roles in RA pathogenesis.

JAK-STAT Expert—DR. POPE

Regulation of the immune response by the JAK family proteins

Introduces and details the structural similarities between the JAK family of proteins (JAK1, JAK2, JAK3, and TYK2). Discusses differences in immunological function between JAK family proteins.

JAK-STAT Expert—DR. EMERY

The role of cytokines in the JAK-STAT pathway

Details JAK-mediated cytokine signalling and highlights key cytokines associated with RA (IL-6, IL-21, GM-CSF) and their role in disease pathogenesis.

Related

JAK-STAT Function

Learn more about the function of the JAK-STAT pathway

Treatment Guidelines

Explore treatment guidelines for patients with RA

Discover our product information for rheumatoid arthritis

GM-CSF, Granulocyte-macrophage colony-stimulating factor; IL, interleukin; JAK, Janus kinase; RA, rheumatoid arthritis; STAT, signal transducer and activator of transcription; TYK, tyrosine kinase.