Rheumatoid Arthritis

 

Patient Perspective


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Overview

Research has come a long way, but RA is still a complex disease to treat

Up to 25% of RA patients in industrialised countries will not achieve low disease activity on biologic or synthetic DMARDs.1 While many patients will achieve ACR20, over 75% of MTX-IR or TNF-IR patients may not achieve low disease activity (i.e., ACR70) on targeted therapies.1

According to treat-to-target recommendations, the absence of remission or low disease activity requires a change in therapy.1 However, response to targeted therapies diminishes with every subsequent line of treatment.2

In RA, there is an increase in rates of serious infections, from less than 1/100 PYs in the healthy population to 5/100 PYs in people with RA.3 Patients with RA also have an increased risk of cardiovascular comorbidities and mortality compared with the general population.4-6

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ACR, American College of Rheumatology; DMARD, disease-modifying antirheumatic drug; HCP, healthcare provider; IR, intolerance or inadequate response; JAK, Janus kinase; PY, patient-year; RA, rheumatoid arthritis; STAT, signal transducer and activator of transcription; TNF tumour necrosis factor.


REFERENCES

1. Aletaha D, Smolen JS. JAMA. 2018;320(13):1360-1372. 2. Rendas-Baum R, Wallenstein GV, Koncz T, et al. Arthritis Res Ther. 2011;13(1):R25. 3. Ravanbod H, Jazayeri J, Russell K, Carrroll G. J Immunol Infect Inflam Dis. 2017;2(3):1-9. 4. Crowson CS, Liao KP, Davis JM 3rd, et al. Am Heart J. 2013;166(4):622-628.e1. 5. Kaplan MJ. Rheum Dis Clin North Am. 2010;36(2):405-426. 6. Aviña-Zubieta JA, Choi HK, Sadatsafavi M, Etminan M, Esdaile JM, Lacaille D. Arthritis Rheum. 2008;59(12):1690-1697.