Galapagos

Inflammatory Conditions

Introduction

Our commitment to inflammation

At Galapagos, we believe we can have a meaningful impact on the lives of millions of people who currently live with an inflammatory disease and we are driven to make a difference.

Autoimmune and chronic inflammatory diseases (AICIDs) occur when the body’s immune system attacks its own cells and causes an inflammatory response.1,2 Chronic inflammatory diseases are currently estimated to affect one in every 20 people in Western society.3 Rheumatoid Arthritis (RA), Ulcerative Colitis (UC) are all examples of inflammatory conditions affecting around 5 million Europeans.4-6

These diseases bear a heavy cost on individuals that are living with the impact of the disease every day. For example, a person living with RA may struggle with simple everyday tasks such as tying their shoelaces or even combing their hair.7 Similarly, a person living with UC may severely limit their social life, relationships and their career out of fear of experiencing symptoms in a public place or with a partner.8


REFERENCES

1. Wang, L., Wang, F. S. & Gershwin, M. E. Human autoimmune diseases: a comprehensive update. J. Intern. Med. 278, 369–395 (2015) 2. Pahwa R, Goyal A, Bansal P, et al. Chronic Inflammation. [Updated 2020 Nov 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK493173/ 3. El-Gabalawy H, Guenther LC, Bernstein CN. Epidemiology of immune-mediated inflammatory diseases: incidence, prevalence, natural history, and comorbidities. J Rheumatol Suppl. 2010 May;85:2-10. doi: 10.3899/jrheum.091461 4. Burisch J, Jess T, Martinato M, Lakatos PL; ECCO -EpiCom. The burden of inflammatory bowel disease in Europe. J Crohns Colitis. 2013 May; 7(4):322-37 5. Galloway J, Capron JP, De Leonardis F, et al. The impact of disease severity and duration on cost, early retirement and ability to work in rheumatoid arthritis in Europe: an economic modelling study. Rheumatol Adv Pract. 2020;4(2):rkaa041. Published 2020 Sep 16. doi:10.1093/rap/rkaa041 6. Taylor PC, Moore A, Vasilescu R, Alvir J, Tarallo M. A structured literature review of the burden of illness and unmet needs in patients with rheumatoid arthritis: a current perspective. Rheumatology International. 2016;36(5):685-95 7. Armuzzi A and Liguori G. Quality of life in patients with moderate to severe ulcerative colitis and the impact of treatment: A narrative review. Digestive and Liver Disease. 2021;53:803-808. 8. Malm K, Bergman S, Andersson MLE, et al. Quality of life in patients with established rheumatoid arthritis: A phenomenographic study. SAGE Open Med. 2017;5:2050312117713647.

Overview


Exploring Ulcerative Colitis